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目的:考察致孔剂普朗尼克F-127以及不同型号聚乳酸-聚羟基乙酸共聚物(poly(lactic-co-glycolic acid),PLGA)配比对于PLGA多孔微球形态和孔洞形成的影响。方法:制备多种处方的PLGA多孔微球,添加不同量的致孔剂普朗尼克F-127,部分不添加任何致孔剂,并且利用PLGA型号为50501A和50502A的不同比例制备多种处方的多孔微球,进行SEM观察缓释多孔微球的整体形态和孔洞。结果:1)添加了不同量的致孔剂普朗尼克F-127的微球,表面的孔洞大小随F-127的添加量成正比关系。2)添加了致孔剂普朗尼克F-127的PLGA微球表面有较多的碎屑粘连,有大量的微球分子破裂,未有添加任何致孔剂的微球,微球的形态较好,球形规整。3)利用不同型号PLGA配比制备的微球SEM图表明,利用PLGA型号为50501A制备的微球表面孔洞清晰,孔洞均匀分布,而利用50502A制备的缓释多孔微球表面的孔洞很少。结论:1)致孔剂普朗尼克F-127会造成小分子的PLGA多孔微球的破裂,不宜作为小分子PLGA多孔微球时的致孔剂。2)不同型号PLGA的配比会对制备的PLGA多孔微球的孔径产生比较大的影响,形成的微球孔径与PLGA的特性粘度成反比。
OBJECTIVE: To investigate the effects of porogen (Pluronic F-127) and polylactic acid-polyglycolic acid (PLGA) on the morphology and pore formation of PLGA porous microspheres. Methods: PLGA porous microspheres with various prescriptions were prepared. Pluronic F-127, a porogen, was added in different amounts. Partially, no porogen was added. Various prescriptions of PLGA model 50501A and 50502A The porous microspheres were observed by SEM to observe the overall morphology and pores of the microspheres. Results: 1) Different amount of Pluronic F-127 porogen was added. The size of the surface pores is proportional to the amount of F-127 added. 2) PLGA microspheres with porogen Pluronic F-127 added had more detritus adhesion, a large number of microsphere molecules were broken, and no microspheres with any porogen were added. Well, the ball is regular. 3) SEM images of microspheres prepared by using different PLGA formulations show that the microspheres prepared by using PLGA model 50501A have clear surface pores and even distribution of holes, while the pores of the surface of sustained-release porous microspheres prepared by 50502A are few. Conclusions: 1) Pluronic F-127, a porogen, can cause the rupture of small molecule PLGA porous microspheres and should not be used as a porogen for PLGA porous microspheres. 2) The ratio of different types of PLGA will have a greater impact on the pore size of the prepared PLGA porous microspheres, and the formed microspheres have an inversely proportional relationship with the intrinsic viscosity of the PLGA.