【摘 要】
：
Human papillomavirus (HPV) infection identified as a definitive human carcinogen is increasingly being recognized for its role in carcinogenesis of human cancers.Up to 38％-80％ of head and neck squamous cell carcinoma (HNSCC) in oropharyngeal location (OPS
【机 构】
：
Department of Clinical Laboratory,Cancer Hospital of the University of Chinese Academy of Sciences (
论文部分内容阅读
Human papillomavirus (HPV) infection identified as a definitive human carcinogen is increasingly being recognized for its role in carcinogenesis of human cancers.Up to 38％-80％ of head and neck squamous cell carcinoma (HNSCC) in oropharyngeal location (OPSCC) and nearly all cervical cancers contain the HPV genome which is implicated in causing cancer through its oncoproteins E6 and E7.Given by the biologically distinct HPV-related OPSCC and a more favorable prognosis compared to HPV-negative tumors,clinical trials on de-escalation treatment strategies for these patients have been studied.It is therefore raised the questions for the patient stratification if treatment de-escalation is feasible.Moreover,understanding the crosstalk of HPV-mediated malignancy and immunity with clinical insights from the pro-portional response rate to immune checkpoint blockade treatments in patients with HNSCC is of importance to substan-tially improve the treatment efficacy.This review discusses the biology of HPV-related HNSCC as well as successful clinically findings with promising candidates in the pipeline for future directions.With the advent of various sequencing technologies,further biomolecules associated with HPV-related HNSCC progression are currently being identified to be used as potential biomarkers or targets for clinical decisions throughout the continuum of cancer care.
其他文献
艾滋病具有病情复杂、发病机制多元,病势深重,呈现多脏器、多系统损害的特点.近年来,中医药防治艾滋病取得了一定的成果,但经方在艾滋病诊疗中的应用相对较少.本文基于对经方的认识,通过对经方治疗艾滋病的临床实践进行分析,认为经方在治疗艾滋病中具有广阔的应用前景,并从基础理论运用和临床科研两方面分析经方治疗艾滋病的思路,以期更好地发挥经方治疗艾滋病的特色和优势,提高经方治疗艾滋病的临床水平.
1月18日,淮委2022年工作会议在蚌埠召开.淮委党组书记、主任刘冬顺出席会议并作题为《锚定六条实施路径 强化流域四个统一 全面推进新阶段淮河保护治理高质量发展》的讲话.他强调,要坚持以习近平新时代中国特色社会主义思想为指导,深入贯彻习近平总书记“十六字”治水思路和关于治水重要讲话指示批示精神,全面落实全国水利工作会议部署,以全面提升流域水安全保障能力为目标,以强化流域治理管理为主线,以建设数字孪生淮河为支撑,锚定“六条实施路径”,强化流域“四个统一”,坚决扛起为淮河代言、为沿淮人民造福、为流域守护水安全
以当代老城区改造过程出现的隔离现象为切入点,从日常生活的视角出发,选取济南老城区具有公共空间异化特征的曲水亭片区作为观察和研究对象,运用以PSPL调研法、动线观察法为核心的多目标导向的人群活动综合调研方法,通过定性与定量相结合的方式解译老城区公共空间中存在的割裂现象和异化表征,并以其中4个典型的街道界面进行“空间-行为”模式的对比分析,总结出“流动型、闭环型、单层隔离型、双层隔离型”4类公共空间异化模式,从而更深层次地揭示公共空间异化产生的动因和机制.最后,在当代存量更新的语境下,基于日常生活与物质空间的
Human endogenous retroviruses (HERVs) were formed via ancient integration of exogenous retroviruses into the human genome and are considered to be viral “fossils”.The human genome is embedded with a considerable amount of HERVs,witnessing the long-term ev
Deep learning has recently been progressively introduced into the field of modulation classification due to its wide application in image,vision,and other areas.Modulation classification is not only the priority of cognitive radio and spectrum sensing,but
Recent breakthroughs in artificial intelligence(AI)give rise to a plethora of intelligent applications and services based on machine learning algorithms such as deep neural networks(DNNs).With the proliferation of Internet of things(IoT)and mobile edge co
The industrial Internet of things(industrial IoT,IIoT)aims at connecting everything,which poses severe challenges to existing wireless communication.To handle the demand for massive access in future industrial networks,semantic information processing is i
Genomic reassortment is an important evolutionary mechanism for influenza viruses.In this process,the novel viruses acquire new characteristics by the exchange of the intact gene segments among multiple influenza virus genomes,which may cause flu endemics
这次会议的主要任务是:深入贯彻习近平总书记“十六字”治水思路和关于治水重要讲话指示批示精神,全面落实全国水利工作会议部署,总结2021年工作,进一步理清新阶段淮河保护治理工作思路,安排2022年重点工作.
2022年1月18日,淮河水利委员会2022年工作会议在蚌埠召开,会议深入学习贯彻习近平总书记“十六字”治水思路和关于治水重要讲话指示批示精神,以及全国水利工作会议部署,总结2021年工作,进一步理清新阶段淮河保护治理工作思路,为淮河流域下一年工作指明了方向.