从微生物次级代谢产物筛选低分子量免疫调节剂,是近几年来寻找新药的一个新动向。七十年代后期,梅泽等发现,各种哺乳动物细胞表面(生物膜)的小分子酶抑制剂(如氨肽酶、碱性磷酸酶、酯酶、cAMP磷酸二酯酶等),有调节免疫功能及其它广泛的生物学活性,从而建立各种有效的筛选方法,系统地筛选了微生物来源的小分子细胞膜酶抑制剂。现已报道的有:Diketocoriolin B、Bestatin、 Screening low molecular weight immunomodulators from microbial secondary metabolites is a new trend in finding new drugs in recent years. The late seventies, Mei Ze and other found that a variety of mammalian cell surface (biofilm) small molecule enzyme inhibitors (such as aminopeptidase, alkaline phosphatase, esterase, cAMP phosphodiesterase, etc.), there is regulation Immune function and other extensive biological activity to establish a variety of effective screening methods, a systematic screening of microbial-derived small cell membrane enzyme inhibitors. Now reported are: Diketocoriolin B, Bestatin,