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在家兔铜绿假单胞菌败血症模型上观察并比较了亚胺培南和头孢他啶单次给药诱导肿瘤坏死因子（ＴＮＦ）产生的过程、强弱及对动物存活的影响；从药物杀菌作用机制方面对结果进行了分析。亚胺培南组血清ＴＮＦ水平从第３～９小时呈现较为平稳的变化过程；头孢他啶组至第７小时出现了第二峰，明显超过对照组和亚胺培南组（Ｐ＜０．０５），其中１只动物死亡，可能与血清ＴＮＦ水平的过度升高有关；使用诱导ＴＮＦ产生较多的药物可能加重了铜绿假单胞菌败血症对机体的损害。抗生素间诱导ＴＮＦ的差异可能与药物作用于不同类型的铜绿假单胞菌青霉素结合蛋白有关。
In the rabbit model of Pseudomonas aeruginosa sepsis were observed and compared imipenem and ceftazidime single-dose induction of tumor necrosis factor (TNF) production process, the strength and impact on animal survival; from the mechanism of drug sterilization The results were analyzed. The level of TNF in the imipenem group showed a stable change from the 3rd to 9th hour. The second peak appeared in the ceftazidime group to the 7th hour, which was significantly higher than that in the control group and imipenem group (P <0.05) , Of which 1 animal died, which may be related to the excessive increase of serum TNF level. The use of more TNF-producing drugs may aggravate the damage of Pseudomonas aeruginosa sepsis to the body. The difference in the induction of TNF between antibiotics may be related to the drug’s action on different types of Pseudomonas aeruginosa penicillin-binding proteins.