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目的:探讨母儿ABO血型不合时孕妇血清中IgG抗体效价对新生儿高胆红素血症发病率的影响。方法:选取2010年1月~2012年12月间于该院分娩的229例ABO血型不合孕妇及其新生儿作为研究对象,测定新生儿高胆红素血症发生率,应用统计学方法对数据进行分析。结果:229例ABO血型不合孕妇中高胆红素血症发病患儿共72例,发病率为31.44%。血清IgG抗体效价1∶64有71例,1∶128有87例,1∶256有53例,效价≥1∶512有18例,新生儿高胆红素血症发病率分别为21.13%、29.88%、39.62%、55.56%。母亲IgG抗A/B抗体效价与新生儿高胆红素血症的发生率相关,抗体效价越高,新生儿高胆红素血症发病率越高,且≥1∶512组与1∶64组相比差异具有统计学意义(χ2=4.81,P<0.05)。结论:孕妇血清中IgG抗体可引起新生儿高胆红素血症,随着IgG抗体效价的增高新生儿高胆红素血症的发病率升高,临床上应加以重视。
OBJECTIVE: To investigate the effect of IgG antibody titers in pregnant women with ABO-incompatible maternal serum on the incidence of neonatal hyperbilirubinemia. Methods: From January 2010 to December 2012 in the hospital during delivery of 229 cases of ABO incompatible pregnant women and their newborns as a study object, the incidence of neonatal hyperbilirubinemia was measured, the application of statistical methods on the data Analyze. Results: A total of 72 children with hyperbilirubinemia were found in 229 cases of ABO incompatible pregnancy with a prevalence of 31.44%. Serum IgG antibody titers 1:64 71 cases, 87 cases of 1:128, 53 cases of 1:256, titers ≥ 1: 512 in 18 cases, the incidence of neonatal hyperbilirubinemia were 21.13% , 29.88%, 39.62%, 55.56%. The maternal IgG anti-A / B antibody titer is related to the incidence of neonatal hyperbilirubinemia. The higher the antibody titer, the higher the incidence of neonatal hyperbilirubinemia, and the ratio of 1: 512 and 1 : 64 group, the difference was statistically significant (χ2 = 4.81, P <0.05). Conclusion: IgG antibodies in pregnant women can cause neonatal hyperbilirubinemia. With the increase of IgG antibody titer, the incidence of neonatal hyperbilirubinemia increased, and should be paid more attention in clinic.