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抑制血管再生可能是治疗实体瘤的有效途径。肿瘤血管生成的主要调控者是血管内皮细胞生长因子(ＶＥＧＦ)。ＶＥＧＦ的 5种异构体中ＶＥＧＦ165是表达丰度最高的异构体 ,ＫＤＲ和Ｆｌｔ 1为ＶＥＧＦ的高亲和受体。1996年Ｓｏｋｅｒ等在各种肿瘤细胞系上发现了仅与ＶＥＧＦ165外
Inhibition of vascular revascularization may be an effective way to treat solid tumors. The main regulator of tumor angiogenesis is vascular endothelial growth factor (VEGF). Of the five isoforms of VEGF, VEGF165 is the most abundant isoform and KDR and Flt 1 are high affinity receptors for VEGF. In 1996, Soker et al. Found only VEGF165 in various tumor cell lines