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目的 :观察吉奥在老年进展期胃癌患者中的应用及对AEG-1/MT qDH、NF-κB、MMP-9水平的影响。方法 :取胃癌患者100例,随机分为对照组(n=45)和观察组(n=45)。对照组采用胃切除术治疗,观察组联合替吉奥化疗治疗,采用免疫组织化学法检测2组患者AEG-1/MT qDH、NF-κB、MMP-9水平,比较两组临床疗效及对AEG-1/MT qDH、NF-κB、MMP-9水平的影响。结果 :观察组治疗后1年生存率、3年生存率及5年生存率,高于对照组;观察组治疗后AEG-1/MT qDH、NF-κB、MMP-9水平,显著低于对照组;观察组治疗后并发症发生率为22.00%,与对照组的18.00%相比差异无统计学意义。结论 :胃癌患者在胃切除治疗基础上联合替吉奥治疗效果理想,能降低AEG-1/MT qDH、NF-κB、MMP-9水平,值得推广应用。
Objective: To observe the application of Gio in elderly patients with advanced gastric cancer and its effects on the levels of qDH, NF-κB and MMP-9 in AEG-1 / MT. Methods: One hundred patients with gastric cancer were randomly divided into control group (n = 45) and observation group (n = 45). The control group was treated with gastrectomy. The observation group was treated with TIGO chemotherapy. The levels of qDH, NF-κB and MMP-9 in AEG-1 / MT were detected by immunohistochemical method. -1 / MT qDH, NF-κB, MMP-9 levels. Results: The 1-year survival rate, 3-year survival rate and 5-year survival rate of the observation group were higher than those of the control group. The levels of qDH, NF-κB and MMP-9 in AEG-1 / MT group were significantly lower than those in the control group Group. The incidence of complications in the observation group was 22.00%, which was not significantly different from that in the control group (18.00%). Conclusion: Gastric cancer patients treated with galectomy combined with gastrectomy are effective and can reduce the levels of qDH, NF-κB and MMP-9 in AEG-1 / MT, which is worth popularizing.