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目的:探讨术毕超声引导下星状神经节阻滞在甲状腺癌患者围手术期中的应用价值。方法:回顾性分析安徽省六安市第二人民医院2018年3月至2019年11月行开放根治术的80例甲状腺癌患者的临床资料。其中，术毕超声引导下星状神经节阻滞40例（观察组），术毕未行超声引导下星状神经节阻滞40例（对照组）。记录两组术后6、12和24 h疼痛数字评分（NRS），术后24 h炎性因子水平[肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）]、术后24 h细胞免疫功能指标（CDn 4+和CDn 8+，并计算CDn 4+/CDn 8+），术前和术后48 h血清甲状旁腺激素（PTH），术后并发症。n 结果:观察组术后6、12和24 h NRS均明显低于对照组[（3.6 ± 0.3）分比（4.3 ± 0.4）分、（2.1 ± 0.2）分比（3.5 ± 0.3）分和（2.6 ± 0.2）分比（3.6 ± 0.3）分]，差异有统计学意义（n P<0.01）。观察组术后24 h TNF-α、hs-CRP和IL-6明显低于对照组[（85.9 ± 6.8）μg/L比（263.5 ± 13.7）μg/L、（6.1 ± 1.6）mg/L比（12.3 ± 2.5）mg/L和（236.9 ± 8.6）μg/L比（388.9 ± 15.5）μg/L]，CDn 4+、CDn 8+和CDn 4+/CDn 8+明显高于对照组（0.036 ± 0.013比0.024 ± 0.010、0.034 ± 0.013比0.026 ± 0.009和1.9 ± 0.1比1.4 ± 0.1），差异有统计学意义（n P0.05），观察组术后48 h PTH明显高于对照组[（29.8 ± 3.9）μg/L比（18.7 ± 2.0）μg/L]，差异有统计学意义（n P<0.01）。观察组术后总并发症发生率明显低于对照组[5.0%（2/40）比25.0%（10/40）]，差异有统计学意义（n χ2 = 4.804，n P<0.05）。n 结论:对于甲状腺癌患者，术毕行超声引导下右侧星状神经节阻滞能有效缓解术后疼痛，减轻炎性反应，提高免疫能力，促进术后甲状旁腺功能恢复，降低术后并发症发生率。“,”Objective:To explore the application value of ultrasound-guided stellate ganglion block in perioperative period of thyroid cancer patients.Methods:From March 2018 to November 2019, in the Second People′s Hospital of Lu′an, Anhui Province, the clinical data of 80 thyroid cancer patients who had underwent open radical operation were retrospectively analyzed. Among them, ultrasound-guided stellate ganglion block was performed in 40 cases (observation group), while ultrasound-guided stellate ganglion block was not performed in 40 cases (control group). The pain digital score (NRS) 6, 12 and 24 h after operation was evaluated. The levels of inflammatory factors, including tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) 24 h after operation were detected. The indexes of cellular immune function (CDn 4+, CDn 8+ and CDn 4+/CDn 8+) 24 h after operation, serum parathyroid hormone (PTH) before operation and 48 h after operation were detected. The postoperative complication was observed.n Results:The NRS 6, 12 and 24 h after operation in observation group were significantly lower than that in control group: (3.6 ± 0.3) scores vs. (4.3 ± 0.4) scores, (2.1 ± 0.2) scores vs. (3.5 ± 0.3) scores and (2.6 ± 0.2) scores vs. (3.6 ± 0.3) scores, and there was statistical difference (n P<0.01). The TNF-α, hs-CRP and IL-6 24 h after operation in observation group were significantly lower than those in control group: (85.9 ± 6.8) μg/L vs. (263.5 ± 13.7) μg/L, (6.1 ± 1.6) mg/L vs. (12.3 ± 2.5) mg/L and (236.9 ± 8.6) μg/L vs. (388.9 ± 15.5) μg/L, the CDn 4+, CDn 8+ and CDn 4+/CDn 8+ were significantly higher than those in control group: 0.036 ± 0.013 vs. 0.024 ± 0.010, 0.034 ± 0.013 vs. 0.026 ± 0.009 and 1.9 ± 0.1 vs. 1.4 ± 0.1, and there were statistical differences (n P0.05); the PTH 48 h after operation in observation group was significantly higher than that in control group: (29.8 ± 3.9) μg/L vs. (18.7 ± 2.0) μg/L, and there was statistical difference (n P<0.01). The incidence of postoperative complication in observation group was significantly lower than those in control group: 5.0% (2/40) vs. 25.0% (10/40), and there was statistical difference (n χ2 = 4.804, n P<0.05).n Conclusions:Ultrasound-guided right stellate ganglion block can effectively relieve postoperative pain, reduce inflammatory reaction, improve immunity, promote the recovery of parathyroid function, and reduce the incidence of postoperative complication in patients with thyroid cancer.