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目的探讨血小板参数和凝血指标水平变化在肝硬化患者中的临床意义。方法肝硬化患者120例为肝硬化组,体检健康者114例为对照组,检测2组血小板计数、平均血小板体积、血小板分布宽度、血小板压积,凝血酶原时间、活化部分凝血酶原时间、凝血酶时间、纤维蛋白原水平,并进行比较。结果肝硬化组血小板计数[(58.46±18.23)×10~9/L]、血小板压积[(0.10±0.04)%]、纤维蛋白原[(1.81±0.69)g/L]明显低于对照组[(186.90±47.52)×10~9/L、(0.24±0.06)%、(2.68±0.54)g/L],平均血小板体积[(13.40±1.34)fL]、血小板分布宽度[(19.64±2.58)fL]明显高于对照组[(11.32±1.14)、(15.62±2.12)fL],凝血酶原时间[(22.76±6.23)s]、活化部分凝血酶原时间[(57.40±7.85)s]、凝血酶时间[(29.62±3.58)s]明显长于对照组[(11.68±1.87)、(35.42±2.49)、(17.34±0.95)s](P<0.05)。结论肝硬化患者血小板参数和凝血指标存在异常,动态检测对临床治疗、病情预后判断有重要意义。
Objective To investigate the clinical significance of the changes of platelet parameters and coagulation indexes in patients with liver cirrhosis. Methods One hundred and seventy patients with cirrhosis were cirrhosis group and 114 healthy subjects were taken as control group. The platelet count, mean platelet volume, platelet distribution width, platelet pressure, prothrombin time, partial prothrombin time, Thrombin time, fibrinogen levels, and compared. Results The platelet count (58.46 ± 18.23) × 10 ~ 9 / L, platelet pressure (0.10 ± 0.04)% and fibrinogen (1.81 ± 0.69) g / L in cirrhosis group were significantly lower than those in control group [(186.90 ± 47.52) × 10 ~ 9 / L, (0.24 ± 0.06)%, (2.68 ± 0.54) g / L], mean platelet volume [(13.40 ± 1.34) fL] and platelet distribution width [(19.64 ± 2.58 ) fL] was significantly higher than that of the control group [(11.32 ± 1.14), (15.62 ± 2.12) fL], prothrombin time [(22.76 ± 6.23) s], partial prothrombin time [(57.40 ± 7.85) s] , The thrombin time [(29.62 ± 3.58) s] was significantly longer than that in the control group [(11.68 ± 1.87), (35.42 ± 2.49), (17.34 ± 0.95) s] (P <0.05). Conclusion There are abnormalities of platelet parameters and coagulation indexes in patients with cirrhosis. Dynamic detection is of great significance for clinical treatment and prognosis judgment.