论文部分内容阅读
目的探讨血清铁蛋白在类风湿性关节炎(RA)疾病诊治和判断疾病活动度的价值。方法收集89例确诊为RA的患者(RA组),收集同期体检的92例健康者(对照组),并根据DAS28进一步分活动期和缓解期,分别检测各组血清铁蛋白、抗环瓜氨酸肽(抗CCP)抗体、C-反应蛋白(CRP)和ESR,并进行统计分析。结果 RA组患者血清铁蛋白水平显著高于对照组,差异有统计学意义(P<0.05),活动期的血清铁蛋白也显著高于缓解期,差异有统计学意义(P<0.05)。SFe与DAS28呈正相关(r=0.485,P<0.05),而与CRP、ESR和抗CCP抗体无相关性(P>0.05)。结论血清铁蛋白不仅可作为RA诊断指标之一,而且是评价RA患者疾病活动性的重要指标。
Objective To investigate the diagnostic value of serum ferritin in the diagnosis and treatment of rheumatoid arthritis (RA) disease. Methods A total of 89 patients with RA (RA group) were collected and 92 healthy subjects (control group) were collected during the same period. Serum ferritin, Acid peptide (anti-CCP) antibodies, C-reactive protein (CRP) and ESR were measured and statistically analyzed. Results The level of serum ferritin in RA group was significantly higher than that in control group (P <0.05). Serum ferritin in active stage was also significantly higher than that in remission stage. The difference was statistically significant (P <0.05). SFe was positively correlated with DAS28 (r = 0.485, P <0.05), but not with CRP, ESR and anti-CCP antibody (P> 0.05). Conclusion Serum ferritin is not only one of the diagnostic criteria for RA, but also an important index to evaluate the disease activity in RA patients.