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目的:研究兵团地区2011年—2015年柯萨奇病毒A组16型(Coxsackievirus A16,CVA 16)的基因亲缘关系。方法:采用一步法RT-PCR扩增标本中CVA16VP1编码区基因并进行测序测定。使用生物学软件构建基因亲缘关系树。结果:本研究获得的49株CVA16流行株的核苷酸和氨基酸相似性分别为90.6%~100.0%和97.6%~100.0%;在系统进化树中全部位于B1b基因分支,并形成了两大一小传播链。各地区的流行株核苷酸的差异和传播情况均有不同。结论:兵团地区2011—2015年流行的CVA16株,形成两大一小传播链,各地区的流行传播情况差异也均有不同。
Objective: To study the genetic relationship of Coxsackievirus A16 (CVA 16) in the Corps from 2011 to 2015. Methods: The gene of CVA16VP1 coding region was amplified by one-step RT-PCR and sequenced. Using Genetics Software to Build Genetic Relationships Trees. RESULTS: The nucleotide and amino acid identities of 49 strains of CVA16 strains obtained in this study were 90.6% -100.0% and 97.6% -100.0%, respectively. All of the strains in the phylogenetic tree were located in the B1b gene branch and formed two major Small spread chain. The prevalence of nucleotide differences and spread among epidemic strains varies across regions. Conclusion: The CVA16 strains prevailing in the Corps region during 2011-2015 formed two major and minor transmission chains, and the differences in prevalence among different regions were also different.