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本研究目的是客观地评价间歇使用硝酸甘油贴膏能否提高运动耐量,减少心绞痛的发作以及预防无症状心肌缺血的发生。方法最初入选14例慢性稳定型心绞痛患者经冠状动脉造影及铊-201心肌灌注显像证实有显著冠脉病变,2例用药后严重头痛而中止治疗,所有患者运动试验均阳性。临床试验采用随机双盲法,治疗开始前5天停
The purpose of this study is to objectively evaluate whether intermittent use of nitroglycerin paste can improve exercise tolerance, reduce the incidence of angina and prevent asymptomatic myocardial ischemia. Methods Initial coronary angiography and thallium-201 myocardial perfusion imaging were performed in 14 patients with chronic stable angina who were initially enrolled in the study. Significant coronary lesions were confirmed in 2 patients, and severe headache was discontinued after medication. All patients were positive in exercise test. Randomized double-blind clinical trials, treatment stopped 5 days before the start