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为了探索定量评价左室肥厚的新方法，本文采用多平面经食管超声心动图三维重建系统，测量了18只实验犬冠状动脉结扎前后的在体心脏左室心肌重量（LVM），并以LVM的解剖学测值为标准对照，与M-型超声Penn氏方法进行了比较。结果显示，冠状动脉结扎前，三维超声心动图（3DE）及Penn氏方法的LVM测值均与其实测值取得了高度相关（r分别为0.95，0.91，SEE分别为2.1g，3.6g），两种方法所测LVM与其实际值间均无显著性差异（P均＞0.1）;冠状动脉结扎后，Penn氏方法的测量结果与LVM实际值的相关性显著下降（r=0.63，SEE=7.9g），而3DE方法的测值仍与LVM的解剖学测值保持高度相关（r=0.96，SEE=2.2g）。表明：3DE可准确测量LVM，且不受左室几何形状的影响，因而在评价高血压合并冠心病患者心肌肥厚时，较之传统的M-型超声Penn氏方法具有显著的优越性。
In order to explore a new method for the quantitative assessment of left ventricular hypertrophy, we used a multiplanar transesophageal echocardiography three-dimensional reconstruction system to measure the left ventricular myocardial mass (LVM) in the heart of 18 experimental dogs before and after ligation of the coronary arteries, Anatomical measurements were taken as standard controls and compared with the M-type ultrasound Penn’s method. The results showed that the LVM values of 3DE and Penn’s method were highly correlated with the measured values before coronary artery ligation (r = 0.95,0.91, SEE = 2.1g, 3.6g, respectively) and two There was no significant difference between the measured LVM and the actual value (P> 0.1). The correlation between Penn’s measurement and actual value of LVM was significantly decreased after coronary artery ligation (r = 0.63, SEE = 7.9g ), While the 3DE method remains highly correlated with the LVM anatomical measurements (r = 0.96, SEE = 2.2 g). It shows that 3DE can accurately measure LVM and is not influenced by left ventricular geometry. Therefore, 3DE has remarkable superiority to traditional M-mode ultrasound Penn’s method in evaluating myocardial hypertrophy in hypertensive patients with coronary heart disease.