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自40年代开始就有人探讨痢疾的免疫疗法,但多发现有局部及全身反应。1964年罗马尼亚学者首用活菌苗对少数病人进行免疫治疗,取得一定成果。近年来有报告利用依链性福氏及宋内氏痢疾菌制成活菌苗用于免疫治疗,但发现对急性期病人可引起炎症加剧和延长粘膜修复等,因此认为对急性痢疾无效,但可用于治疗慢性痢疾。本文使用苏联医科院戈玛利亚研究所的福氏痢疾菌的自然突变株(S.flexneri 2a 516M)制成活菌苗
Some people have been discussing immunotherapy for dysentery since the 1940s, but many have found local and systemic reactions. In 1964, Romanian scholars firstly used the live vaccine to immunize a few patients and achieved some results. In recent years, it has been reported that the use of live-bacteriostatic vaccines based on Streptovertic and Salivary dysentery can be used for immunotherapy. However, it has been found that acute diarrhea is not effective in patients with acute phase which can cause inflammation and prolonged mucosal repair Can be used to treat chronic dysentery. In this paper, a natural mutant of S.flexis (S.flexneri 2a 516M) from the Gomari Institute of the Soviet Medical Institute was used to make live vaccine