随着治疗性单克隆抗体在临床治疗方面发挥的作用日益突显,其全球药物市场所占份额和研发投入均在逐年增加。除了抗体新药的开发,抗体药物效力和安全性相关的基因工程改造也越来越受到重视。在这些基因工程改造中,抗体半衰期改造已成为近年来研究的热点之一。对几种抗体半衰期改造技术进行了介绍,并简要描述了半衰期改造后抗体的临床研究现状。 With the increasingly prominent role of therapeutic monoclonal antibodies in clinical treatment, their global pharmaceutical market share and R & D investment are increasing year by year. In addition to the development of new drug antibodies, more attention has been paid to the genetic engineering of antibody drug efficacy and safety. In these genetic engineering, antibody half-life modification has become one of the hot spots in recent years. Several antibody half-life modification techniques were introduced, and the clinical status of antibody after half-life modification was briefly described.