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目的：观察静注参麦注射液对实验性油酸型急性呼吸窘迫综合征（ＡＲＤＳ）的影响。方法：静脉注射油酸（０．１ｍｌ／ｋｇ）复制家兔ＡＲＤＳ的动物模型，随后立即静脉注射参麦注射液（１０ｍｌ／ｋｇ），观察在ＡＲＤＳ发展过程中白细胞介素－１（ＩＬ－１）、肿瘤坏死因子（ＴＮＦ）、血气，２ｈ后处死动物检测肺组织匀浆ＩＬ－１、ＴＮＦ活性及病理改变，并与模型组做比较。结果：参麦注射液可明显缓解油酸所致的急性肺损伤，改善低氧血症，经统计学处理后治疗组与模型组相比，血浆ＩＬ－１，ＴＮＦ在１２０ｍｉｎ（Ｐ＜０．０５），肺组织匀浆ＩＬ－１、ＴＮＦ治疗组与模型组相比较亦降低（Ｐ＜０．０５）。结论：提示参麦注射液可明显减轻所致的急性肺损伤，对防治ＡＲＤＳ有一定的作用
Objective: To observe the effect of intravenous Shenmai injection on experimental oleic acid type acute respiratory distress syndrome (ARDS). METHODS: An animal model of rabbit ARDS was intravenously injected with oleic acid (0.1 ml/kg), followed by intravenous injection of Shenmai injection (10 ml/kg) immediately to observe interleukin-1 (IL-1) during the development of ARDS. ), Tumor necrosis factor (TNF), blood gas, 2 h after the animals were sacrificed to determine the activity of lung homogenate IL-1, TNF and pathological changes, and compared with the model group. Results: Shenmai injection can alleviate acute lung injury caused by oleic acid and improve hypoxemia. After statistical treatment, the plasma IL-1 and TNF in the treatment group were compared with the model group at 120 min (P<0. 05), the lung tissue homogenate IL-1, TNF treatment group compared with the model group also decreased (P <0.05). Conclusion: It is suggested that Shenmai injection can significantly reduce the acute lung injury caused by it, and it has a certain effect on the prevention and treatment of ARDS.