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目的研究维持性血液透析的尿毒症患者氧化应激以及免疫功能的变化,为尿毒症透析治疗提供指导依据。方法选取于本院血液透析室规律透析的尿毒症患者、年龄相仿的健康人各30例,分别对其进行T淋巴细胞群、NK细胞、免疫球蛋白等免疫指标以及CRP、IL-6、MDA、Hcy等氧化应激指标的测定(尿毒症患者分别测透析前后各指标)并比较分析。结果尿毒症透析后较透析前CRP升高,IL-6、MDA、Hcy降低,免疫球蛋白、T淋巴细胞亚群、NK细胞升高,差异有统计学意义(P<0.05)。结论维持性血液透析会加重尿毒症患者的氧化应激状态,充分透析有助于改善免疫功能状态。
Objective To study the changes of oxidative stress and immune function in maintenance hemodialysis patients with uremia and provide guidance for the treatment of uremia dialysis. Methods Thirty patients with uremia regularly dialyzed in our hospital and 30 healthy individuals of the same age were enrolled. The immune indexes such as T lymphocyte population, NK cells and immunoglobulin, as well as CRP, IL-6, MDA , Hcy and other indicators of oxidative stress (uremia patients were measured before and after dialysis each index) and comparative analysis. Results After uremia dialysis, the levels of CRP, IL-6, MDA and Hcy, immunoglobulin, T lymphocyte subsets and NK cells in dialysis were significantly higher than those before dialysis (P <0.05). Conclusion Maintenance hemodialysis can aggravate oxidative stress in patients with uremia, and adequate dialysis can improve the immune function.