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近些年来临床上多用葡萄糖注射液和生理盐水等输液和多种抗生素配合后给病人静脉点滴。但因葡萄糖注射液和生理盐水可与多种抗生素发生相互作用而降低疗效,还使心、肾功能不全的水肿患者及糖尿病患者应用受到限制。近年来实验研究和临床观察发现,甲硝唑注射液(pH为4.5～7),与常用的大多数抗生素如红霉素、青霉素、氨苄青霉素、头孢唑啉、头孢拉定等混合后,化学性质稳定,抗菌活性增强,抗菌范围扩大,并能减少液体输入量、减轻病人心脏负荷。对要限制液体输入量又需静滴抗生素的严重混合感染患者尤为适用。举例如下:
In recent years, clinical use of glucose injection and saline infusion and a variety of antibiotics with intravenous drip to the patient. But glucose injection and saline can interact with a variety of antibiotics to reduce the effect, but also to heart and kidney dysfunction in patients with edema and diabetes limited application. In recent years, experimental study and clinical observation found that metronidazole injection (pH 4.5 ~ 7), and most commonly used antibiotics such as erythromycin, penicillin, ampicillin, cefazolin, cefradine and other mixed, chemically stable , Enhanced antibacterial activity, expanded antibacterial range, and can reduce the liquid input, reduce the patient’s heart load. This is especially true for patients with severe mixed infections that need to be infused with antibiotics to limit fluid intake. For example: