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为了探讨组胺 H2 受体拮抗剂和质子泵抑制剂静脉给药对胃酸的抑制作用。 2 0例十二指肠球部溃疡患者 ,随机分为 5组。每组 4例 ,进行胃内 2 4小时 pH监测。结果显示 :用药后各组 pH >4,pH >6的时间 ,洛赛克 1、2组与奥美拉唑组分别为 999.0± 416 .4、6 6 1.8± 45 6 .6分钟 ,132 0 .0± 6 6 .1、114 0 .0± 2 2 2 .0分钟和 10 5 0 .0± 30 0 .0、870 .0±336 .0分钟 ,法莫替丁组为 336 .6± 14 4 .0、79.8± 32 .4分钟 ,雷尼替丁组为 2 0 4.0± 18.0、10 0 .2± 2 2 .8分钟。质子泵抑制剂组明显长于H2 受体拮抗剂组。H2 受体拮抗剂常规剂量一次用药 ,胃内 pH控制不理想。提示 :当十二指肠溃疡合并出血时 ,宜使用质子泵抑制剂。
To investigate the inhibition of gastric acid by intravenous administration of histamine H2 receptor antagonists and proton pump inhibitors. Twenty patients with duodenal ulcer were randomly divided into 5 groups. 4 cases in each group, the stomach 24 hours pH monitoring. The results showed that the time of pH> 4 and pH> 6 in each group after treatment was 999.0 ± 416.4,66 1.8 ± 45.6 and 6 minutes .0 ± 6 6 .1,114 0 .0 ± 2 2 2 .0 minutes and 105 0 .0 ± 30 0 .0,870 .0 ± 336 .0 minutes, the famotidine group was 336 .6 ± 14 4 .0,79.8 ± 32.4 minutes, ranitidine group 2.0 ± 4.0 ± 18.0, 10.2 ± 2.2 2.8 minutes. Proton pump inhibitor group was significantly longer than H2 receptor antagonist group. H2 receptor antagonist conventional dose of a drug, gastric pH control is not satisfactory. Tip: When duodenal ulcer bleeding, it is appropriate to use proton pump inhibitors.