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Ehrlich(1877)发现肥大细胞存在于各种动物不同器官的结缔组织内,其胞质的颗粒中含有组织胺等生物活性物质。近来在人中耳渗液及实验动物引起的中耳炎性渗液中均发现含量较高的组织胺,从而推测肥大细胞在中耳炎的发病中起着一定的作用。作者在本文中对正常人鼓室粘骨膜及急、慢性中耳炎时中耳活检标本的肥大细胞进行了定性及定量研究,病理标本取自70个病人(男39,如1人),共83份。其中急性炎症26,慢性炎症57,两组肥大细胞计数的对比采用方差分析。
Ehrlich (1877) found that mast cells exist in connective tissues of different organs of various animals and their cytoplasmic granules contain bioactive substances such as histamine. Recently in human middle ear effusion and experimental animals caused by otitis media exudation were found in higher levels of histamine, suggesting that mast cells in the pathogenesis of otitis media play a role. In this paper, the normal and tympanic mucoperiosteal mucosa and acute and chronic otitis media in the middle ear biopsy specimens of mast cells were qualitative and quantitative analysis of pathological specimens from 70 patients (39 male, such as 1), a total of 83. Including acute inflammation 26, chronic inflammation 57, two mast cell count comparison analysis of variance.