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糖尿病视网膜病变(DR)是一种发生进行性视力损害的糖尿病(DM)并发症,其特征是毛细血管闭锁、微循环障碍和局部缺血性视网膜新生血管形成,其确切的发病机制尚不清楚。最近有研究认为DR可能与视网膜毛细血管炎症反应有关。由于细胞因子能引起炎症反应和黏附分子表达,因此细胞因子增加单核细胞和内皮细胞黏附的过程被认为是DR发生发展过程中的关键事件。就血管内皮生长因子(VEGF)、转化生长因子-β(TGF-β)、碱性成纤维细胞生长因子(bFGF)等多种细胞因子在DR中的作用进行综述。
Diabetic retinopathy (DR) is a diabetic complication of progressive visual impairment characterized by atresia of capillaries, microcirculation and ischemic retinal neovascularization whose exact pathogenesis is unclear . Recent studies suggest that DR may be related to retinal capillary inflammation. Because cytokines can cause inflammation and expression of adhesion molecules, the process by which cytokines increase the adhesion of monocytes and endothelial cells is considered as a key event in the development and progression of DR. The roles of vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), basic fibroblast growth factor (bFGF) and other cytokines in DR were reviewed.