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目的:探讨健脾消积颗粒对脾虚大鼠胃液、胃酸分泌及胃蛋白酶活性的影响。方法:用大黄造成大鼠脾虚模型后,再灌服健脾消积颗粒药液,于末次灌胃后1 h,测定大鼠胃液、胃酸分泌量、胃蛋白酶活性。结果:健脾消积颗粒的胃液、胃酸分泌量和胃蛋白酶的活性与模型组比较,差异具有统计学意义(P<0.05或P<0.01)。结论:健脾消积颗粒对脾虚大鼠的健脾作用机制之一与其能使脾虚大鼠的胃液、胃酸分泌增加、胃蛋白酶活性提高有关。
Objective: To investigate the effects of Jianpi Xiaoshi granules on gastric juice, gastric acid secretion and pepsin activity in rats with spleen deficiency. Methods: After the rat model of spleen deficiency was induced by rhubarb, the rats were treated with “Jianpi Xiaoshi granules”, and the gastric juice, gastric acid secretion and pepsin activity were measured 1 h after the last gavage. Results: The contents of gastric juice, gastric acid secretion and pepsin in Jianpi Xiaoshi granules were significantly different from those in model group (P <0.05 or P <0.01). Conclusion: One of the mechanism of spleen-invigorating and spleen-invigorating granules on spleen-invigorating rats is related to the increase of gastric juice and gastric acid secretion and the increase of pepsin activity.