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以培养的大鼠血管内皮细胞为模型，观察了精氨酸加压素对其脂质过氧化的影响及相关血管活性肽的调节作用，旨在探讨ＡＶＰ等血管活性肽对ＶＥＣ脂质过氧化的影响及与高血压病发病的关系。结果表明：（１）１０－７Ｍ的ＡＶＰ作用后，ＶＥＣ的丙二醛含量明显高于对照组（Ｐ＜０．０１）；（２）１０－７Ｍ的降钙素基因相关肽（ＣＧＲＰ）、Ｐ物质分别与１０－７Ｍ的ＡＶＰ共同作用后，ＶＥＣ的ＭＤＡ含量均减少，与ＡＶＰ对照组比较差异非常显著（Ｐ＜０．０１）。此表明，ＡＶＰ可能通过增强ＶＥＣ脂质过氧化作用引起ＶＥＣ损伤，与高血压病发病有一定关系。ＣＧＲＰ、ＳＰ对ＡＶＰ有拮抗作用
The cultured rat vascular endothelial cells as a model to observe the effects of arginine vasopressin on lipid peroxidation and the regulation of related vasoactive peptides, to explore the vasoactive peptides such as AVP VEC lipid peroxidation And its relationship with the incidence of hypertension. The results showed that: (1) The content of MDA in VEC after 10-7M AVP treatment was significantly higher than that in control group (P <0.01); (2) CGRP of 10-7M, After substance P and 10-7M AVP, respectively, the content of MDA in VEC decreased, which was significantly different from that in AVP control group (P <0.01). This shows that, AVP may enhance VEC lipid peroxidation caused VEC injury, and the incidence of hypertension has a certain relationship. CGRP, SP antagonizes AVP