血小板来源的生长因子(PDGF)系由巨核细胞产生,存在于血小板α颗粒内,当血小板凝集时被释放出来。PDGF是一种糖蛋白,多以S-S结合形式存在,经酸、热处理后不丧失活性,经还原剂处理后,S-S链被切断,分成A、B两条多肽链,其增殖作用随即消失。PDGF能促进间叶系细胞的血管平滑肌细胞和纤维母细胞以及神经胶质细胞等许多细胞的增殖,而对士皮来源的细胞、血管内皮细胞或淋巴细胞却无此作用。据认为猴肉瘤病毒V-sis基因的产物与 Platelet-derived growth factor (PDGF) is produced by megakaryocytes and is present in platelet alpha particles and is released when platelets agglutinate. PDGF is a kind of glycoprotein, mostly exists in the form of S-S binding. After being treated with acid and heat, it does not lose activity. After treatment with a reducing agent, the S-S chain is cut and divided into two polypeptide chains A and B, and its proliferation disappears. PDGF can promote the proliferation of many cells such as vascular smooth muscle cells and fibroblasts and glial cells in mesenchymal cells, but it has no effect on the epidermis-derived cells, vascular endothelial cells or lymphocytes. It is believed that the V-sis gene of monkey sarcoma virus