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目的探讨小牛血去蛋白提取物辅助治疗恶性肿瘤患者放射性肺炎的临床疗效。方法选择2013年8月至2014年12月间诊治的82例放射性肺炎患者,根据患者入院顺序分为研究组和对照组,每组各41例。两组患者均给予糖皮质激素、抗生素等常规治疗,研究组患者加用小牛血去蛋白提取物治疗,对两组患者的临床效果进行评价。结果研究组患者的咳嗽、呼吸困难和肺部啰音缓解时间均显著低于对照组,差异均有统计学意义(均P<0.05)。治疗前两组患者的白介素6(IL-6)、IL-10、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)水平的差异均无统计学意义(均P>0.05),治疗后两组患者的IL-6、IL-10、TNF-α和CRP水平较治疗前均明显下降(均P<0.05),研究组患者降低更加明显(均P<0.05)。治疗前两组患者的放射性肺炎分级差异无统计学意义(P>0.05),治疗后两组患者的放射性肺炎分级均显著优于同组治疗前,差异有统计学意义(P<0.05),治疗后研究组患者放射性肺炎分级显著优于对照组,差异有统计学意义(P<0.05)。经过2周治疗,研究组患者的完全缓解率为56.1%,显著高于对照组的31.7%,差异有统计学意义(P<0.05);治疗后研究组患者的部分缓解率、无效率与对照组比较,差异均无统计学意义(均P>0.05)。结论小牛血去蛋白提取物辅助治疗恶性肿瘤患者放射治疗致放射性肺炎能够显著提高临床效果。
Objective To investigate the clinical efficacy of deproteinized calf blood in the adjuvant treatment of radiation pneumonitis in patients with malignant tumors. Methods Eighty-two patients with radiation pneumonitis who were diagnosed and treated between August 2013 and December 2014 were divided into study group and control group according to the order of hospital admission, with 41 cases in each group. Two groups of patients were given glucocorticoid, antibiotics and other conventional treatment, the study group plus bovine serum albumin extract treatment, the clinical effect of two groups of patients were evaluated. Results The cough, dyspnea and pulmonary rales in the study group were significantly lower than those in the control group (all P <0.05). There were no significant differences in the levels of IL-6, IL-10, TNF-α and CRP between the two groups before treatment (all P> 0.05) The levels of IL-6, IL-10, TNF-α and CRP in the latter two groups were significantly lower than those before the treatment (all P <0.05), and the patients in the study group were more obviously decreased (all P <0.05). There was no significant difference in the classification of radiation pneumonitis between the two groups before treatment (P> 0.05). After treatment, the classification of radiation pneumonitis in both groups was significantly better than that in the same group before treatment (P <0.05) Post-study group of patients with radiation pneumonitis grading significantly better than the control group, the difference was statistically significant (P <0.05). After 2 weeks of treatment, the complete remission rate of the study group was 56.1%, which was significantly higher than that of the control group (31.7%), the difference was statistically significant (P <0.05). After treatment, the partial remission rate and inefficiency of the study group were significantly lower than those of the control group There was no significant difference between the two groups (all P> 0.05). Conclusions Radiation-induced radiation pneumonitis can be significantly improved in the adjuvant treatment of deproteinized calf blood serum in patients with malignant tumors.