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目的探讨血清白细胞介素(IL)-10水平的检测在鼻咽癌诊治中的临床价值。方法采用ELISA法,检测60例鼻咽癌患者和20例正常人血清IL-10水平,并对部分患者放疗前后的血清IL-10水平进行动态观察。结果鼻咽癌患者血清IL-10水平明显高于正常对照组(P<0.005);Ⅰ和Ⅱ期患者血清IL-10水平明显低于Ⅲ和Ⅳ期患者(P=0.011);有颈淋巴结转移或远处转移患者的血清IL-10水平稍高于无颈淋巴结转移或远处转移患者,但差异无统计学意义(P>0.05)。放疗后获得肿瘤局部控制患者的血清IL-10水平明显低于放疗前(P<0.001)。结论血清IL-10水平检测在鼻咽癌的诊断、分期和疗效观察中具有一定的临床价值。
Objective To investigate the clinical value of serum interleukin-10 (IL-10) in the diagnosis and treatment of nasopharyngeal carcinoma. Methods Serum levels of IL-10 in 60 patients with nasopharyngeal carcinoma and 20 normal controls were detected by ELISA. The levels of serum IL-10 in some patients before and after radiotherapy were observed. Results Serum levels of IL-10 in patients with nasopharyngeal carcinoma were significantly higher than those in normal controls (P <0.005). Serum levels of IL-10 in patients with stage I and II were significantly lower than those in patients with stages III and IV (P = 0.011) Or distant metastasis of patients with serum IL-10 levels slightly higher than those without cervical lymph node metastasis or distant metastasis, but the difference was not statistically significant (P> 0.05). Serum IL-10 levels were significantly lower in patients with locally advanced tumor after radiotherapy than before radiotherapy (P <0.001). Conclusion Serum IL-10 levels in the diagnosis of nasopharyngeal carcinoma, staging and efficacy of observation has some clinical value.