论文部分内容阅读
目的 探讨非卵黄囊瘤的ＡＦＰ 阳性卵巢恶性肿瘤的病理组织形态和临床生物学行为。方法 报道４ 例非卵黄囊瘤的ＡＦＰ 阳性卵巢恶性肿瘤，１ 例为单纯肝样癌，３ 例为有梭形细胞成分的内膜样癌（ 其中１ 例伴有肝样癌） 。结果 肝样癌癌细胞的胞质内含有ＡＦＰ、ＡＡＴ 和ＡＣＴ 成分，而在内膜样癌癌细胞的胞质内以ｃｙｔｏｋｅｒａｔｉｎ 和ＣＥＡ 成分为主。由于ＡＦＰ 具有免疫抑制作用，病人的预后不好。４ 例中３ 例已死亡，平均生存２５ 个月，１ 例现存活７ 个月，仍在随访中。结论 此类癌瘤具有独特的病理组织形态特征和高度恶性的临床生物学行为。
Objective To investigate the pathological morphology and clinical biological behavior of non-yolk sac tumor of AFP positive ovarian cancer. Methods Four cases of AFP positive ovarian cancer without yolk sac tumor were reported. One was simple hepatic carcinoma and the other three was endometrioid carcinoma with spindle - shaped cells (one of them was associated with hepatic carcinoma). Results Liver-like cancer cells contained cytoplasmic AFP, AAT and ACT components, while cytokeratin and CEA components were predominant in the cytoplasm of endometrioid cancer cells. Due to the immunosuppressive effects of AFP, the patient’s prognosis is poor. Of the 4 patients, 3 had died, with an average survival of 25 months and 1 surviving for 7 months and were still under follow-up. Conclusion These carcinomas have unique histopathological features and highly malignant clinical biological behaviors.