bcr/ab1嵌合基因在白血病病因方面的直接作用知之甚少。本文报告的ph~+白血病小鼠模型的建立,表明P190直接参与一种起病急、演变快、恶性程度高的白血病的发生。从体内证实Ph染色体与人类白血病的因果关系,有助于增进对这一疾病的认识和治疗方案的快速评估。作者用一个bcr/ab1基因构件(P190/MT)转 The direct role of bcr / ab1 chimeric genes in the etiology of leukemia is poorly understood. The establishment of the mouse model of ph ~ + leukemia reported in this paper indicates that P190 is directly involved in the onset of acute leukemia with rapid progression and high malignancy. The corroboration of the Ph chromosome with human leukemia in vivo has helped to improve the understanding of the disease and the rapid assessment of treatment options. The authors used a bcr / ab1 gene construct (P190 / MT) to turn