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【目的】探讨1型糖尿病患者外周血趋化因子 CCL21表达水平及其意义。【方法】将30例1型糖尿病患者按病程不同分为3组：A组（病程＜2个月）12例、B组（2个月≤病程＜3年）10例和C组（病程≥3年）8例，用酶联免疫吸附法（ELISA ）检测3组患者及20例健康儿童（对照组）外周血中CCL21水平。【结果】1型糖尿病患者外周血中CCL21表达显著高于对照组（ P＜0．01），随着病程的延长，CCL21表达水平呈下降趋势，差异有显著性（ P ＜0．05）。【结论】1型糖尿病患者外周血中CCL21表达增高，并随病程的延长而下降。“,”[Objective]To explore the expression of chemokine CCL 21 in peripheral blood of patients with type 1 di-abetes and its significance .[Methods] According to the course of disease ,30 patients with type 1 diabetes were divided into group A(the course<2 months ,n=12) ,group B(2 months≤the course<3 years ,n=10) and group C(the course≥3 years ,n=8) .The levels of CCL21 in peripheral blood of patients in 3 groups and 20 healthy children(control group) were determined by ELISA method .[Results]The expression of CCL21 in peripheral blood of patients with type 1 diabe-tes was markedly higher than that of control group ( P<0 .01) .The expression of CCL21 was decreased with the exten-sion of the course .There was significant difference ( P <0 .05) .[Conclusion] The expression of CCL21 in peripheral blood of patients with type 1 diabetes is increased ,and decreased with the extension of the course .