目的:对米非司酮治疗子宫肌瘤的临床效果进行观察分析。方法:收治的50例子宫肌瘤患者为临床资料,50例患者均采用米非司酮治疗,观察治疗前、服药3个月后、停药6个月后的具体效果。结果:50例患者在服药3个月后子宫及子宫肌瘤体积较治疗前显著缩小(p<0.05),分别缩小27.4%和43.8%,下腹坠胀感、痛经等症状消失,5例患者肌瘤完全消失;在停药6个月后50例患者中31例(62.00%)患者肌瘤未出现明显增大,19例(38.00%)患者有不同程度增大;服药3个月后50例患者雌激素(E2)、黄体生成素(LH)、孕酮(P)及卵泡刺激素(FSH)水平较治疗前显著降低(p<0.05),在停药6个月后19例患者较服药3个月后的水平明显回升(p<0.05);在服药期间50例患者中2例(4.00%)患者出现阴道分泌物减少的不良反应,5例(10.00%)轻微的多汗、潮热等绝经期症状,7例(14.00%)食欲减退、恶心症状,该类患者在停药后均自行恢复,所有患者经过常规检查显示肝肾功能正常。结论:临床治疗子宫肌瘤使用米非司酮能够获得较佳的短期疗效,长期疗效并不稳定,不过其有着费用低、不良反应少的特点,是米非司酮非手术治疗的理想药物,具有一定的推广价值。 Objective: To observe and analyze the clinical effect of mifepristone in treating uterine fibroids. Methods: 50 patients with uterine fibroids were treated as clinical data, 50 patients were treated with mifepristone, observed before treatment, medication 3 months after stopping the specific effect after 6 months. Results: The volume of uterine and uterine fibroids was significantly reduced in 50 patients (27.4% vs 43.8%, respectively) after 3 months of treatment. The symptoms of lower extremities were dilated, symptoms of dysmenorrhea disappeared, and 5 cases of muscle Tumor completely disappeared; 31 cases (62.00%) of 50 patients did not appear to have fibroids increased significantly after 6 months withdrawal, and 19 cases (38.00%) patients increased in varying degrees; 50 cases The levels of estrogen (E2), LH, P and FSH in patients were significantly lower than those before treatment (p <0.05). After 6 months’ withdrawal, 19 patients were treated After 3 months, the level of the vaginal discharge increased significantly (p <0.05). Two patients (4.00%) out of the 50 patients in the medication group had adverse reactions of vaginal discharge reduction. Five patients (10.00% And other menopausal symptoms, 7 cases (14.00%) loss of appetite, nausea symptoms, these patients were self-recovery after stopping, all patients after routine examination showed normal liver and kidney function. Conclusion: The clinical treatment of uterine fibroids with mifepristone can obtain better short-term curative effect, long-term curative effect is not stable, but it has the characteristics of low cost and few adverse reactions, it is the ideal drug for non-surgical treatment of mifepristone, Has a certain promotional value.