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目的了解安徽省首例W135群流行性脑脊髓膜炎(流脑)病例的发病特点及流行病学特征,及时掌握安徽省流脑菌群变迁动向。方法查阅病例的病案资料;开展流行病学调查;采集病例血标本、密切接触者咽拭子标本进行病原培养和基因型别检测。结果患者临床表现为高热、剧烈头痛、呕吐、惊厥、皮肤瘀点瘀斑、休克等;无流脑疫苗免疫史,无流脑病例或疑似流脑病例接触史。从病例血液标本中检出1株W135群脑膜炎奈瑟菌(Nm),从病例密切接触者咽拭子标本中检出4株W135群Nm。对病例Nm和2株密接Nm进行MLST基因序列检测,结果均为ST-11型。结论该病例为安徽省首例W135群流脑病例,其MLST基因序列为ST-11型。
Objective To understand the incidence and epidemiological characteristics of the first case of epidemic cerebrospinal meningitis (meningitis) in W135 in Anhui Province and to grasp the trend of the migratory of meningococci in Anhui Province in time. Methods Investigate the medical records of the cases; carry out epidemiological investigation; collect the blood samples of the cases and the throat swabs of the close contacts for pathogen culture and genotype detection. Results The clinical manifestations of patients with high fever, severe headache, vomiting, convulsions, ecchymosis, shock, etc; no history of meningitis vaccine immunization, no meningitis cases or suspected cases of meningitis contact history. One W135 Neisseria meningitidis group (Nm) was detected from the blood samples of the case and four W135 groups of Nm were detected from the throat swab samples of close contacts. The MLST gene sequence was tested on case Nm and 2 strains of Nm. The results were all ST-11. Conclusion This case is the first case of W135 hermaphroditism in Anhui Province. The MLST gene sequence is ST-11.