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目的探讨急性脑梗死患者血清超敏C-反应蛋白(hs-CRP)的动态变化及其与脑梗死体积、病情严重程度之间的相关关系。方法 48例急性脑梗死患者,于发病后第1、3、7、14天抽取空腹静脉血3 ml,采用免疫比浊法测定血清hs-CRP水平,同期收集30例健康体检者作为正常对照组,分析hs-CRP与急性脑梗死患者神经功能缺损程度及脑梗死体积大小的相关关系。结果脑梗死组hs-CRP在发病后第1、3、7、14天均高于对照组(P<0.05),但只有第3天显著高于对照组(P<0.05);梗死体积大脑梗死患者hs-CRP含量大于梗死体积小的脑梗死患者,在病后第7天比较有统计学意义(P<0.05)。结论 hs-CRP参与了急性脑梗死的发生发展过程。
Objective To investigate the dynamic changes of serum hs-CRP in patients with acute cerebral infarction and its relationship with the volume of cerebral infarction and the severity of the disease. Methods Forty-eight patients with acute cerebral infarction received fasting venous blood 3 ml on the 1st, 3rd, 7th and 14th days after the onset of illness. Serum hs-CRP levels were measured by immunoturbidimetry and 30 healthy subjects were collected as normal control group , The relationship between hs-CRP and the degree of neurological deficits and cerebral infarction volume in patients with acute cerebral infarction was analyzed. Results The hs-CRP levels in cerebral infarction group were significantly higher than those in control group on the 1st, 3rd, 7th and 14th days (P <0.05), but only on the third day (P <0.05) Patients with hs-CRP greater than the infarct size of small cerebral infarction patients, compared to the first 7 days after the disease was statistically significant (P <0.05). Conclusion hs-CRP is involved in the development of acute cerebral infarction.