论文部分内容阅读
目的:研究胃小细胞癌(SCCS)的临床病理特征。方法:本文对22例SCCS的病理形态进行观察,14例做NSE、ChromograninA、CEA、Cytokeratin免疫组化染色,6例行电镜观察。结果:SCCS占同期胃癌的2.5％(22/1600例),中、晚期浸润性癌占95.4％,在SCCS分型中复合型12例,纯小细咆癌6例,混合性2例。19/22例有淋巴结转移,占86.7％;侵犯脉管和神经各占10例(45.5％)和5例(22.7％);肝转移相远处淋巴结转移各1例。小细胞成份NSE、Chromogranin A轻至中度表达,腺或鳞癌分化区域CEA、Cytokeratin轻至中度表达,3例电镜下找到神经内分泌颗粒。结论:SCCS同肺小细胞癌一样,是高度恶性的神经内分泌癌,并伴有多向分化的特征,应与胃低分化腺癌区分。
Objective: To study the clinicopathological features of gastric small cell carcinoma (SCCS). Methods: The pathological morphologies of 22 cases of SCCS were observed in this study. 14 cases were immunohistochemically stained for NSE, Chromogranin A, CEA and Cytokeratin. Six cases underwent electron microscopy. Results: SCCS accounted for 2.5% (22/1600) cases of gastric cancer in the same period, 95.4% of invasive carcinomas in the middle and late stages, 12 cases of complex type in SCCS classification, 6 cases of pure small fine orbital carcinoma, and 2 cases of mixed type. 19/22 patients had lymph node metastasis, accounting for 86.7%; invading vessels and nerves accounted for 10 cases (45.5%) and 5 cases (22.7%); liver metastasis distant lymph node metastasis in 1 case. Small cell components NSE, Chromogranin A light to moderate expression, glandular or squamous cell carcinoma differentiation CEA, Cytokeratin mild to moderate expression, 3 cases of neuroendocrine particles were found under electron microscope. CONCLUSIONS: SCCS, like small cell lung cancer, is a highly malignant neuroendocrine carcinoma with multilineage characteristics and should be distinguished from poorly differentiated adenocarcinoma of the stomach.