据报导,大鼠在棕曲霉毒素A(OA)中毒晚期可出现大量的出血灶;在幼龄鸡中可引起再钙化作用、凝血酶原时间显著延长及凝血因子浓度下降。为此,作者进行了对大鼠与OA有关的出血性综合症的病理生理学研究。实验用体重为235.8±7.5 g的雄性Wistar大鼠,随机分成五组(1组对照组24只、4组实验组各14只),自由摄食与饮水。溶OA于等渗的碳酸氢钠溶液中经食道插管授予,四个 It has been reported that a large number of hemorrhagic foci may appear in late stages of browning toxin A (OA) poisoning in rats; recalcification may occur in young chickens, prothrombin time is significantly prolonged, and coagulation factor concentrations are decreased. To do this, the authors performed a pathophysiological study of OA-associated hemorrhagic syndrome in rats. Experimental male Wistar rats weighing 235.8 ± 7.5 g were randomly divided into five groups (24 in one control group and 14 in each of the four experimental groups). They were fed with water freely. Dissolution of OA in isotonic sodium bicarbonate solution is granted via the esophageal intubation, four