论文部分内容阅读
目的:观察探讨滋阴活血方对糖尿病视网膜病变大鼠血清炎症相关因子表达的影响。方法:对SD大鼠尾静脉注射4.5%链脲菌素诱导糖尿病模型。将糖尿病大鼠随机分为模型对照组、多贝斯治疗组、滋阴活血组,灌胃治疗6周。于治疗后采取各组大鼠采取尾静脉血,离心后测定血清中白介素6型(IL-6)、肿瘤坏死因子α(TNF-α)以及C反应蛋白(CRP)水平。结果:喂养6周后,模型组、多贝斯组大鼠血清TNF-α、IL-6、CRP水平明显高于正常对照组(P<0.05)。滋阴活血方灌胃组大鼠TNF-α、IL-6、CRP水平可见明显低于糖尿病模型组(P<0.05),均有不同程度的下降。结论:滋阴活血方可对糖尿病视网膜病变大鼠全身的炎症反应起到一定的控制作用。
Objective: To observe the effect of Ziyin Huoxue Recipe on the expression of serum inflammation related factors in diabetic retinopathy rats. Methods: SD rats were injected with 4.5% streptozotocin-induced diabetic model via the tail vein. The diabetic rats were randomly divided into model control group, Dobes treatment group, nourishing Yin and activating blood group, and intragastric administration for 6 weeks. After treatment, the rats in each group were taken tail vein blood and serum levels of IL-6, TNF-α and CRP were measured after centrifugation. Results: After 6 weeks of feeding, the serum levels of TNF-α, IL-6 and CRP in the model group and the Dobasia group were significantly higher than those in the normal control group (P <0.05). The levels of TNF-α, IL-6 and CRP in rats fed with nourishing Yin and promoting blood circulation group were significantly lower than those in diabetic rats (P <0.05), all of which decreased in varying degrees. Conclusion: Ziyin Huoxue can play a certain role in controlling the systemic inflammatory response in diabetic retinopathy rats.