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目的:探讨血浆致动脉硬化指数(AIP)及血纤维蛋白原(FBG)水平与冠心病(CHD)患者冠状动脉(冠脉)病变程度之间的关系。方法:队列入选568例患者,其中经冠脉造影证实CHD患者374例(CHD组),冠脉造影正常者194例(对照组),所有患者均测量收缩压(SBP)、舒张压(DBP)、TG、TC、LDL-C、HDL-C、FBG、空腹血糖(FBS)等指标,并进行统计学处理。结果:①与对照组相比,CHD组SBP、DBP、FBG、FBS、AIP、TG、TC和LDL-C水平较高及HDL-C水平较低(P<0.05);②单因素方差分析显示,在病变程度不同亚组间比较,AIP随病变程度加重呈升高趋势,但差异无统计学意义;多支病变亚组的FBG水平明显高于其他患者(P<0.05);③Spearman等级相关分析显示,AIP、FBG均与冠脉病变程度呈正相关(r=0.525,r=0.242,P<0.01)。结论:AIP与FBG在CHD患者中具有较高水平,为CHD的独立危险因素。
Objective: To investigate the relationship between the plasma levels of atherosclerosis index (AIP) and fibrinogen (FBG) in patients with coronary heart disease (CHD). Methods: A total of 568 patients were enrolled in the cohort. Among them, 374 CHD patients (CHD group) and 194 normal coronary artery patients (control group) were confirmed by coronary angiography. All patients were measured SBP, DBP, , TG, TC, LDL-C, HDL-C, FBG, fasting blood glucose (FBS) and other indicators, and statistical analysis. Results ① Compared with the control group, the levels of SBP, DBP, FBG, FBS, AIP, TG, TC and LDL-C in CHD group were higher and the HDL-C level was lower (P < (P <0.05). The Spearman rank correlation analysis showed that the level of FBG in subgroups of multi-vessel disease was significantly higher than that in other subgroups (P <0.05). The levels of AIP increased with the severity of disease in subgroups with varying degrees of disease, but the difference was not statistically significant Show, AIP, FBG and coronary artery disease were positively correlated (r = 0.525, r = 0.242, P <0.01). Conclusion: AIP and FBG have high levels in patients with CHD and are independent risk factors for CHD.