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目的探讨河南地区汉族人群乙肝后肝硬化遗传易感性与人类白细胞抗原DRB1等位基因多态性的关系,为探寻乙肝后肝硬化的易感基因和抵抗基因提供线索。方法应用聚合酶链反应-序列特异性引物技术,对62例河南汉族乙肝后肝硬化患者、90例慢性乙型肝炎患者及62例正常健康人进行了HLA-DRB1等位基因检测,应用统计学软件SPSS10.0对三组实验结果进行χ2检验。结果在乙肝后肝硬化组中HLA-DRB1*1201/1202等位基因频率显著升高,与慢性乙型肝炎组及健康组对比,差异均有统计学意义,而HLA-DRB1*1301/1302、1501/1502等位基因实验组与两组对照组相比较均无统计学差异。结论HLA-DRB1*1201/1202等位基因可能为河南地区汉族人群乙肝后肝硬化形成的易感基因。
Objective To explore the relationship between genetic susceptibility to hepatitis B cirrhosis and human leukocyte antigen DRB1 alleles in Han nationality in Henan province and provide clues for exploring the susceptibility genes and resistance genes in patients with posthepatitic cirrhosis. Methods HLA-DRB1 alleles were detected in 62 Han patients with Hepatitis B cirrhosis, 90 Chronic Hepatitis B patients and 62 healthy controls by polymerase chain reaction-sequence-specific primer technique. Application statistics Software SPSS10.0 three groups of experimental results χ2 test. Results The frequencies of HLA-DRB1 * 1201/1202 alleles in patients with posthepatitic cirrhosis were significantly higher than those in patients with chronic hepatitis B and healthy controls (P <0.01), but HLA-DRB1 * 1301 / 1501/1502 allele experimental group compared with the two control groups were no significant difference. Conclusion HLA-DRB1 * 1201/1202 alleles may be susceptible genes for the formation of posthepatitic cirrhosis in Han nationality in Henan province.