对3年前接种过3针血源性乙肝疫苗的10名无应答和弱应答者以及52名应答良好者各复种1针血源性乙肝疫苗。无应答和弱应答者大部分抗-HBs阳转,其滴度明显升高,但持续时间较短。52名良好应答者复种后多数出现良好的回忆反应。1μg疫苗皮内注射显示了同10μg肌肉注射相似的应答效果。复种后的抗体应答水平与初种后的抗体应答峰值呈明显正相关。 10 non-responders and weak responders who received 3-needle-sourced Hepatitis B vaccine 3 years ago, and 52 patients who responded well to each of the 1-needle Hepatic Hepatitis B Vaccine. Most of the non-responders and the weak responders had positive anti-HBs and their titers were significantly increased, but their duration was shorter. Most of the 52 respondents showed good recall response after multiple-cropping. An intradermal injection of 1 μg vaccine showed similar response to 10 μg intramuscular injection. The level of antibody response after the multiplication was positively correlated with the peak of antibody response after the first seed.