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目的探讨亚低温和依达拉奉联合治疗大面积脑梗死的临床疗效。方法大面积脑梗死患者40例,随机分入亚低温和依达拉奉治疗组20例,对照组20例,于治疗前及治疗后不同时间分别对患者进行神经功能缺损评分(nds),观察病死率、有效率等指标。结果与对照组相比治疗组能显著减少神经功能缺损,有效率75%,差异有统计学意义(P<0.01),但未降低病死率。结论亚低温和依达拉奉联合治疗大面积脑梗死疗效显著,应加以应用。
Objective To investigate the clinical effect of mild hypothermia and edaravone in treating large area cerebral infarction. Methods Forty patients with large area cerebral infarction were randomly divided into mild hypothermia and edaravone 20 cases and control group 20 cases. Neurological impairment scores were observed before and after treatment. Fatality rate, efficiency and other indicators. Results Compared with the control group, the treatment group could significantly reduce the neurological deficit, the effective rate was 75%, the difference was statistically significant (P <0.01), but did not reduce the mortality. Conclusion The combination of mild hypothermia and edaravone is effective in treating large-area cerebral infarction and should be applied.