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目的探讨川崎病(KD)发生冠状动脉损伤(CAL)的危险因素及多脏器损害发生情况。方法回顾性分析175例KD患儿的临床资料,对伴CAL患儿31例、无CAL患儿144例的资料进行对照研究,对12种影响CAL发生的因素进行统计学分析。结果伴CAL患儿在年龄、静脉输注免疫球蛋白(IVIG)时间、热程、血红蛋白(Hb)、红细胞压积(Hct)等方面,与无CAL患儿比较,差异有统计学意义(P<0.05);CAL患儿左室扩大和心包积液的发生率高于无CAL患儿(P<0.05)。结论年龄<6个月、热程和IVIG治疗时间延迟、Hb和Hct降低是KD发生CAL的高危险因素。
Objective To investigate the risk factors of coronary artery lesions (CAL) in Kawasaki disease (KD) and the occurrence of multiple organ damage. Methods The clinical data of 175 children with KD were retrospectively analyzed. The data of 31 children with CAL and 144 children without CAL were compared and the 12 factors influencing the occurrence of CAL were analyzed statistically. Results There was a significant difference in the age, IVIG time, heat stroke, hemoglobin (Hb) and hematocrit (Hct) among children with CAL compared with those without CAL <0.05). The incidence of left ventricular enlargement and pericardial effusion in CAL children was higher than that in children without CAL (P <0.05). Conclusions Age <6 months, delayed heat stroke and IVIG treatment, and decreased Hb and Hct are high risk factors for KD.