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以LDH作为细胞损伤的指标,观察双光气对豚鼠呼吸道的损伤作用。豚鼠吸入双光气的剂量为Lct 50左右,支气管—肺灌洗液LDH活性是182±27单位％,对照组是29±7单位％,两者差异显著,中毒组灌洗液中游离血红蛋白含量不升高,表明增加的LDH不来源于红细胞。肾上腺素组灌洗液LDH活性值和中毒组灌洗液LDH同工酶谱,都提示增加的LDH来自呼吸道细胞。这些结果证明双光气对豚鼠呼吸道细胞有直接损伤作用。
To LDH as an indicator of cell damage, observe the phosgene on the respiratory tract of guinea pig injury. In guinea pigs, the dose of phosgene was Lct 50, the LDH activity in bronchoalveolar lavage fluid was 182 ± 27 units%, and the control group was 29 ± 7%. There was significant difference between the two groups in the free hemoglobin content in lavage fluid Does not increase, indicating that increased LDH does not come from the red blood cells. The LDH activity of the epinephrine group lavage fluid and LDH isoenzyme pattern of the lavage fluid of the poisoning group all suggest that the increased LDH is from the respiratory tract cells. These results demonstrate that diphosgene has a direct traumatic effect on the respiratory cells of guinea pigs.