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目的探讨平阳霉素瘤体内注射治疗乳腺癌术后局部复发的效果及其临床意义。方法常规消毒后根据病灶大小选4～7号注射器针头 ,穿刺点在病灶中心部位 ,将针头先刺入病灶深部再退到中心 ,缓慢注药 ,使药液逐渐弥散整个病灶而不溢于皮下 ,注入药量依病灶大小而定 ,一般每次8～24mg,7d注射1次 ,通常注射2～3次肿瘤即可消失。结果病灶直径≤2.0cm者38例 ,注药1～2次即消失 ,占63 % ,病灶直径超过3.0cm者需注药3～5次方可消失。病灶越小 ,效果越好。结论4例病灶直径3.0～3.5cm左右 ,注药5次后局部变硬稍隆起 ,观察1个月后行手术切除 ,病理组织学检查所见 :癌细胞变性、坏死及周围组织纤维化。这充分表明 ,本方法疗效可靠。
Objective To investigate the effect and clinical significance of intraperitoneal injection of pingyangmycin in the treatment of postoperative local recurrence of breast cancer. Methods According to the size of the lesion, the number of needles was chosen according to the size of the lesion. The puncture point was in the center of the lesion. The needle was inserted into the lesion and then retreated to the center. The drug was injected slowly so that the solution gradually dispersed throughout the lesion without over- , Depending on the size of the injection dose may be, usually each 8 ~ 24mg, 7d injection 1, usually injected 2 to 3 times the tumor can disappear. Results 38 cases of lesion diameter ≤ 2.0cm, injection 1 or 2 times disappear, accounting for 63%, lesion diameter of more than 3.0cm need to inject 3 to 5 times before disappear. The smaller the lesion, the better the effect. Conclusions The diameters of the lesions in 4 cases were about 3.0 ~ 3.5cm. After 5 times of injection, the lesions were partially hardened and slightly bulged. Surgical resection was performed after 1 month. Pathological examination revealed degeneration and necrosis of cancer cells and fibrosis of the surrounding tissues. This fully shows that the method is reliable.