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皮肤白血病的诊断是根据主要细胞的类型、浸润模式和有关的特征性临床表现和血液学所见,组织化学可能有助于最后确诊。作者对42例皮肤白血病患者皮肤进行了组织病理和组织化学研究,并根据细胞起源分析了白血病浸润的组织病理模式,以探讨是否仅通过活检就可得到白血病型的精确诊断。42例中急性淋巴细胞性白血病(ALL)3例,慢性(CLL)16例:急性粒细胞性白血病(AGL)12例、慢性(CGL)3例;急性单核细胞性白血病(AML)5例;急性髓性单核细胞性白血病(AMML)3例。结果:大体上皮肤白血病真皮和皮下组织有弥漫性的白血病细胞浸润,浸润常常在胶原束之间。表皮
The diagnosis of cutaneous leukemia is based on the type of primary cell, the mode of infiltration and the associated characteristic clinical manifestations and hematology findings, histochemistry may be helpful in the final diagnosis. The authors performed a histopathological and histochemical study on the skin of 42 patients with leukemia and analyzed the histopathological patterns of leukemia infiltration based on the origin of the cells to investigate whether the leukemia type can be accurately diagnosed by biopsy alone. Of the 42 patients, 3 were acute lymphoblastic leukemia (ALL) and 16 were chronic (CLL): 12 with acute myeloid leukemia (AGL), 3 with chronic (CGL), 5 with acute monocytic leukemia (AML) ; Acute myelomonocytic leukemia (AMML) in 3 cases. RESULTS: In general dermal leukemia dermis and subcutaneous tissue have diffuse leukemic cell infiltrates, often infiltrating between collagen bundles. epidermis