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序列特异的ＤＮＡ结合蛋白ｃｍｙｃ在细胞的增殖与分化过程中起着十分重要的调节作用,并能诱导细胞凋亡。反义ｃｍｙｃＲＮＡ,采用ｃｍｙｃ基因含有起始密码子的第二外显子及其两侧部分内含子序列,共1.53ｋｂ片段构建而成,具有抑制ｃｍｙｃ表达的作用[1]。本研究以腺病毒介导,
The sequence-specific DNA binding protein cmyc plays an important regulatory role in cell proliferation and differentiation, and can induce apoptosis. Antisense cmycRNA, using the second exon of the cmyc gene containing the start codon and its intron partial sequences on both sides, was constructed from a total of 1.53 kb fragment and had the effect of inhibiting the expression of cmyc [1]. This study was mediated by adenovirus,