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对妊高征孕妇血清中ALP,HSAP及HPL,SP_1的变化进行检测,结果ALP、HSAP、随孕周增加而增高,38～39孕周达高峰。两者在孕期中呈正相关(r=0.88、P<0.05)。HPL、SP_1随孕周增加而增高38孕周达高峰。 重度妊高征时,ALP明显升高,而HSAP明显减低,ALP与HSAP呈分离现象。重度妊高征时此分离现象尤为显著P<0.01。HPL、SP_1在重度妊高征时与轻度妊高征有显著性差异P<0.01。ALP/HSAP、HPL、SP_1,测定不仅可以反映胎盘功能同时也可以判断妊高征的严重程度。
The changes of serum ALP, HSAP and HPL, SP_1 in pregnant women with PIH were detected. The results showed that ALP and HSAP increased with the increase of gestational age and peaked at 38-39 gestational weeks. The two were positively correlated during pregnancy (r = 0.88, P <0.05). HPL, SP_1 increased with gestational age increased 38 weeks reached its peak. Severe pregnancy-induced hypertension, ALP was significantly increased, while HSAP was significantly reduced, ALP and HSAP were isolated. Severe pregnancy-induced hypertension when the phenomenon of this separation was particularly significant P <0.01. HPL, SP_1 in severe PIH with mild PIH have significant differences P <0.01. ALP / HSAP, HPL, SP_1, not only can reflect the determination of placental function, but also can determine the severity of PIH.