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本文用紫外分光光度法对大型和中型药铜宫形节育器在体外进行90天内每天消炎痛的释放量及第120、150和180天的释放量测定。结果表明,两种型号的节育器具有相同的释放特征。在第1个月内,药物呈瀑布样释放,其累计量分别为总含量的53.19%和52.04%,以后释放量逐日减缓,至3个月后趋于稳定,释放时间可维持7~8个月。
In this paper, large and medium-sized bronchial IUDs were used to measure the release of indomethacin and the release of 120, 150 and 180 days per day in vitro. The results show that both types of IUDs have the same release profile. In the first month, the drug showed a waterfall-like release, the cumulative amount of which was 53.19% and 52.04% of the total respectively. After that, the release gradually slowed down to a stable level after 3 months and the release time could be maintained 7 to 8 months.