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目的:优选消湿膏的成型工艺。方法:以光泽性、均匀细腻度、涂展性、黏度为指标,对凝胶基质中卡伯姆的用量进行考察;以保湿率为指标,采用正交试验对甘油、丙二醇用量进行考察;以羟基萘醌总色素为评价指标,通过体外透皮实验,分别对冰片、丙二醇、氮酮及其组合的透皮促进作用进行考察。结果:消湿膏基质最佳处方为:卡波姆-9403.3%,甘油10%,丙二醇15%,冰片1.5%,氮酮2.9%,三乙醇胺适量,山梨酸钾为配制总重的1‰。结论:根据新确定的基质处方制成的消湿膏有光泽、均匀细腻、光滑、黏度适宜,按《中华人民共和国药典》检验符合凝胶剂的标准。
Objective: To optimize the forming process of deodorant paste. Methods: The amount of Carbopol in the gel matrix was investigated with glossiness, uniform fineness, spreading ability and viscosity. The orthogonal test was used to study the dosage of glycerol and propylene glycol with Hydroxynaphthoquinone total pigment as an evaluation index, through in vitro transdermal experiments, respectively, on the borneol, propylene glycol, azone and their combination of transdermal promoting effect were investigated. Results: The best prescription of Humid ointment was carbomer -9403.3%, glycerol 10%, propylene glycol 15%, borneol 1.5%, azone 2.8%, triethanolamine appropriate and potassium sorbate 1% of the total weight. Conclusion: According to the newly established matrix prescription moisturizing cream made of glossy, uniform, smooth, suitable viscosity, according to the “People’s Republic of China Pharmacopoeia” test in line with the standard gel.