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目的:建立简便、成功率高、远期肾静脉血栓发生率低的大鼠肾移植模型。方法:SD大鼠为供受体。切除受体左肾,采用自行设计的供体腹腔动脉、硬膜外导管内撑法重建动脉血供。供体后腔静脉与受体近后腔静脉处肾静脉端端吻合。结果:供体手术时间为(42±3)min;受体手术时间为(90±10)min。供体器官热缺血时间为≤2s,冷缺血时间≤100min。53例次手术中,成功48例,手术成功率为90.6%(48/53)。无远期并发症。结论:改良后的大鼠肾移植模型,保留了原术式操作简单、对手术器械和术者的显微外科技能要求低、成功率高等优点、又降低了肾静脉血栓等远期并发症的发生率,可作为慢性排斥反应的动物研究模型。
Objective: To establish a simple, high success rate, long-term renal vein thrombosis incidence in rats with low renal transplantation model. Methods: SD rats served as recipients. The left kidney was excised, and the donor’s celiac artery was designed by ourselves. The epidural catheter was used to reconstruct the arterial blood supply. The posterior vena cava of the donor and the proximal vena cava of the recipient end anastomosis. Results: The time of donor operation was (42 ± 3) min and the duration of operation was (90 ± 10) min. Donor organ ischemia time ≤ 2s, cold ischemia time ≤ 100min. In 53 cases of subtasal surgery, 48 cases were successful, the success rate of surgery was 90.6% (48/53). No long-term complications. CONCLUSION: The improved model of rat kidney transplantation retains the advantages of simple operation, minimal requirement of microsurgery for surgical instruments and surgeons, high success rate and lower long-term complications such as renal vein thrombosis The incidence of chronic rejection can be used as a model of animal studies.