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本工作在戊巴比妥钠麻醉的家兔上进行。采用夹闭肠系膜上动脉阻断血流方法建立内毒紫休克的实验模型。用放射免疫分析法测定了休克前后脑区、脑脊液及血浆中脑啡肽含量的变化,并观察了脑室或静脉注射纳洛酮的抗休克效应。结果如下:1.休克时,下丘脑、延脑、桥脑的亮脑啡肽含量显著升高,中脑无明显变化、丘脑、纹状体下降。脑脊液和血浆中亮脑啡肽明显增加。外周静脉血与肾静脉血中无显著差别。2.侧脑室或静脉注射纳洛酮,均可使休克动物的血压回升,延长存活时间。脑室注射的升压数值略大,维持升压时间也较长。实验结果提示:脑啡肽参与内毒素休克过程。断阿片样物质的作用,可能是治疗内毒素休克的一个途径。
This work was performed on rabbits anesthetized with pentobarbital sodium. An experimental model of endotoxic Violet shock was established by occluding the superior mesenteric artery and blocking blood flow. Radioimmunoassay was used to determine the changes of enkephalins in brain, cerebrospinal fluid and plasma before and after shock, and the anti-shock effect of intraventricular injection of naloxone was observed. The results are as follows: 1. Shock, hypothalamus, medulla oblongata, pontine enkephalin content was significantly elevated, no significant changes in the midbrain, thalamus, striatum decreased. Cerebrospinal fluid and plasma leupeptin increased significantly. No significant difference between peripheral venous blood and renal venous blood. Lateral ventricle or intravenous injection of naloxone, shock animals can make the blood pressure rise, prolong survival time. Ventricular injection of the boost slightly larger value to maintain a longer boost time. The experimental results suggest that enkephalin is involved in endotoxic shock process. Opioid opioid function may be a way to treat endotoxic shock.