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目的:分析三金排石汤对特发性钙结石患者24小时尿成石危险因素水平的影响,探讨其用于预防手术取石后的特发性钙结石患者结石复发的临床价值。方法:选择2009年9月~2013年9月入住我院的经皮肾镜取石术或输尿管镜取石术治疗的特发性钙结石患者100例,前瞻性将其随机分为治疗组和观察组,两组各50例。治疗组予三金排石汤每日一剂分两次煎服,观察组予正常饮食,测定和比较两组患者治疗前和治疗1个月后的24小时尿成石危险因素水平。结果:治疗1个月后,观察组24小时尿成石危险因素水平与治疗前比较差异均无统计学意义(P>0.05);治疗组24小时尿量较治疗前显著增加,尿pH值、尿枸橼酸含量明显升高,尿钙显著降低,差异均有统计学意义(P<0.05),但尿钠、尿镁、尿磷、尿尿酸及尿草酸水平与治疗前比较差异均无统计学意义(P>0.05);与观察组比较,治疗组24小时尿量明显增加,尿pH值、尿枸橼酸含量显著升高,尿钙水平明显降低,差异均有统计学意义(P<0.05),但两组尿钠、尿镁、尿磷、尿尿酸及尿草酸水平比较差异均无统计学意义(P>0.05)。结论:三金排石汤治疗手术取石后特发性钙结石患者能够显著增加其24小时尿量及尿枸橼酸含量,并减少尿钙含量,抑制结石形成,这可能有助于降低特发性钙结石患者手术取石后的复发风险,值得临床研究和推广。
Objective: To analyze the influence of Sanjin Paishi Decoction on the 24-hour urinary calcification risk factors in patients with idiopathic calcium stone and to discuss the clinical value of Sanjin Paishi Decoction in preventing stone recurrence in patients with idiopathic calcium stone after operation. Methods: One hundred patients with idiopathic calculus who underwent percutaneous nephrolithotomy or ureterolithotomy in our hospital from September 2009 to September 2013 were prospectively randomized into treatment group and observation group , 50 cases in both groups. The treatment group to three gold Paishi decoction two times daily dose of decoction, the observation group to the normal diet, determination and comparison of two groups of patients before treatment and after treatment for 24 hours urinary stone risk factors. Results: After 1 month of treatment, the 24-hour urinary calcification risk factors in the observation group were not significantly different from those before treatment (P> 0.05); the urine output of 24 hours in the treatment group was significantly higher than that before treatment, Urine citric acid was significantly increased, urinary calcium was significantly lower, the difference was statistically significant (P <0.05), but urine sodium, urinary magnesium, urinary phosphorus, uric acid and urinary oxalate levels compared with before treatment were no statistical differences (P> 0.05). Compared with the observation group, the urinary volume in the treatment group increased significantly in 24 hours, the urinary pH value and urine citric acid content increased significantly and the urinary calcium level decreased significantly (P < 0.05). However, there was no significant difference in urinary sodium, urinary magnesium, urinary phosphorus, urinary uric acid and urinary oxalate between the two groups (P> 0.05). Conclusion: Sanjin Paishi Decoction in patients with idiopathic calculi after operation can significantly increase its 24-hour urine output and urinary citrate content, and reduce urinary calcium content, inhibit the formation of stones, which may help to reduce idiopathic Calcified stones in patients with stone surgery after the recurrence risk, it is worth clinical research and promotion.